ENO2 and Creutzfeldt Jacob disease: Examples include Plasmodium vivax aldolase and P. falciparum glyceraldehyde-3-phosphate dehydrogenase for malaria [60,61], tumor M2-pyruvate kinase for gastrointestinal cancer [62], human α-enolase for Behcet’s disease and cancer [63], neuron-specific enolase to differentiate Creutzfeldt-Jakob disease from other illnesses characterized by dementia [64], and enolase for both human and canine leishmaniasis [65].