Recent studies investigating mRNA expression of S100 proteins in correlation with the survival of ovarian cancer patients demonstrated that high levels of the S100 family members S100A2, S100A10, S100A11, S100A15, S100A16, and S100B predict worse OS, while S100A1, S100A3, S100A5, S100A6, S100A13, S100G, and S100Z are associated with longer OS, partially depending on cancer subtype and clinicopathological features [144,145]. The gene discussed is S100A2; the disease is cancer.