The expression of several S100 family members, namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8, S100A9, S100A10, S100A11, S100A13, and S100B, were detected in melanoma tissue, partially depending on the cancer stage [76,126]. The gene discussed is S100A9; the disease is melanoma.