Further investigation of S100B in an ADC-derived brain metastasis cell line showed that depletion of S100B resulted in the downregulation of pro-survival factors, namely B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma extra-large (Bcl-xL), both inhibitors of apoptosis, indicating that S100B suppresses apoptosis in these cancer cells. The gene discussed is S100B; the disease is cancer.