Intracellular S100A7 interacts with the transcriptional cofactor constitutive photomorphogenesis 9 (COP9) constitutive photomorphogenic homolog subunit 5 (COPS5), also known as c-Jun activation domain-binding protein-1 (Jab1), which then accumulates in the nucleus and promotes the expression of AP-1 and NF-κB, resulting in enhanced tumour growth and invasion [104]. Here, COPS5 is linked to neoplasm.