Nevertheless, S100A14 seems to have tumour-suppressing properties in oral cancer, as overexpression of S100A14 in OSCC cell lines resulted in suppression of invasion, associated with the downregulation of MMP1 and MMP9, as well as decreased proliferation, correlating with upregulation of p21 and G1 cell cycle arrest [201,202]. This evidence concerns the gene S100A14 and neoplasm.