The transcription factor p53 is an important tumour suppressor, and among other functions also regulates DNA replication and induces the transcription of pro-apoptotic proteins such as phorbol-12-myristate-13-acetate-induced protein 1 (NOXA) and p53 upregulated modulator of apoptosis (PUMA) [55]. The gene discussed is PMAIP1; the disease is neoplasm.