Similarly, the lncRNA HIF2PUT (hypoxia-inducible factor-2α (HIF-2α) promoter upstream transcript), the promoter-associated ncRNA of the HIF-2α gene, can inhibit proliferation, self-renewal, and migration of osteosarcoma stem cells by regulating the expression of HIF-2α [68]. This evidence concerns the gene EPAS1 and osteosarcoma.