Particularly, pncCCND1_B decreases the rate of lysine acetylation of the histone H3 in the CCND1 promoter region whereas Sam68 is necessary for the chromatin localization of pncCCND1_B. Sam68 forms a multimolecular complex composed by pncCCND1_B and the RNA/DNA helicase DXH9 in Ewing sarcoma cells. This evidence concerns the gene KHDRBS1 and Ewing sarcoma.