FAP and neoplasm: By developing CAR-T cells against fibroblast activation protein (FAP; a proteinase involved in extracellular matrix remodelling, expressed abundantly in epithelial cancers [166]), Wang et al. [167] demonstrated that clearance of cancer-associated stromal cells (CASCs) by FAP CAR-T cells inhibits tumour growth and increases tumour infiltration by host immune cells.