Furthermore, a study showed that CD90+ Huh7 cells (HCC cell line) secreted exosomes harboring H19, a lncRNA, and once in the target cells, it upregulated the expression and release of VEGF, thus stimulating angiogenesis and the adherence of CD90+ Huh7 cells to endothelial cells [78], further stressing the importance of VEGF as a target for RNAi. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.