T-regs play a role in the attenuation of the NK cell’s function, either by the release of cytokines such as IL-8, TGF-ß1 and IL-10—which then decrease the expression of NK receptors’ ligands on HSCs, preventing them from binding to the NK group 2D receptor on NK cells—or by their competition with NK cells for the available IL-2 in the tumor microenvironment [139]. This evidence concerns the gene IL10 and neoplasm.