MAPK1 and hepatocellular carcinoma: Additionally, in order to inhibit the proliferation of HCC cell lines (HepG2 and Huh7), siRNA targeting a tyrosine kinase receptor known as macrophage-stimulating protein receptor was shown to efficiently suppress tumor cell migration and invasion and enhance apoptosis by activating cleaved caspase-3 and poly (ADP-ribose) polymerase through the modulation of the Akt, c-Raf and ERK signaling pathway [110].