Another study showed that M2 macrophages accumulated more in Sorafenib-resistant HCC tumors than in Sorafenib-sensitive ones, and confer Sorafenib resistance by secreting HGF, which sustains tumor growth and metastasis by the activation of the HGF/c-Met, ERK1/2/MAPK and PI3K/AKT pathways in tumor cells [107]. The gene discussed is MAPK3; the disease is hepatocellular carcinoma.