In a study in nine obese subjects with insulin resistance but normal triacylglycerolemia, the consumption of a high GI mixed meal, compared with a low GI one, increased the postprandial rise in plasma insulin and the accumulation of TRL-apoB-48 and TRL-apoB-100 at 4 and 2 h postprandially, respectively, thus increasing postprandial TG concentrations [123]. The gene discussed is INS; the disease is Insulin resistance.