INS and diabetes mellitus: Physiological studies with mixed meals showed that fasting and postprandial triglycerides were also negatively associated with the blood flow response in the subcutaneous adipose tissue of individuals across the whole spectrum of metabolic derangement, i.e., normoglycemic but insulin-resistant first-degree relatives of patients with diabetes, prediabetic patients and patients with diabetes but solely postprandial hyperglycemia, and, finally, patients with overt diabetes but treatment-naïve [32].