On the other hand, while miR-155 expression was also higher in the serum of EBV-positive DLBCL patients [38], interestingly, miR-155-binding to the Pdl1 3′UTR actually served to upregulate PD-L1 expression, further demonstrating the complex nature of miRNA-mediated gene regulation [39]. Here, CD274 is linked to diffuse large B-cell lymphoma.