These antecedents may explain why the increase in total BID expression in cells exposed to UV-inactivated Wt1-5 did not lead to an increase in active Bax concentration, caspase-3, and cytochrome C. Previous data reported by others suggest that most childhood ALL cell lines (RCH, Reh, SUP B15, and HAL01) rarely have mutations in p53 in the case of B-cell precursors, although they may be more frequent in Burkitt lymphoma [97,98,99]. The gene discussed is BAX; the disease is acute lymphoblastic leukemia.