DSPE-PEG-B6, high affinity for transferrin receptor (TfR), DSPE-PEG-Mazindol (MA), a high affinity dopamine transporter, DSPE-PEG-phenylboronic acid, loading epigallocatechin gallate (EGCG), and INOPs were self-assembled to treat PD. The gene discussed is TFRC; the disease is Parkinson disease.