GAPDH and cancer: However, in cancer cells exhibiting normally high glucose demands, exacerbated glucose consumption generates ROSs which, in turn, increase Poly (ADP-ribose) polymerase (PARP) and inhibit Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by increasing the amount of glyceraldehyde-6-phosphate and by creating a pathway for the MGO formation [57].