HAVCR2 and neoplasm: Again, the most frequent immune targets in CD4+ T cells from patients with GBM, in descending order, isolated from the tumor microenvironment were A2aR > PD-1 > CTLA-4 > CD39 > TIGIT > FOXP3 > LAG-3 > CD160 > TIM3 > KIR > CD73.