MYC and acute lymphoblastic leukemia: The formation of the i(8q) results in a duplication of the proto‐oncogene c‐Myc mapping at 8q24.2, which has been shown to provide selective growth advantage in vitro.55, 56, 57 In AML and ALL, i(8q) is considered to arise as a secondary clonal abnormality contributing to disease progression and is often found in conjunction with complex karyotypes.58, 59