TP53 and cancer: For instance, the absence of the der(4) in the B‐1 cell line, which is however present in MV‐4‐11, RS4;11, AN4;11, and SEM, suggests that it is the der(11) to detain a pivotal role in the promotion and maintenance of the malignancy.79, 80 Differences in other molecular features, such as mutations of known cancer‐related genes TP53 and FLT3, can prove useful in investigating the role of point mutations in leukaemogenesis77, 78, 81 (Table 2).