The dermatosparaxis (ADAMTS2, MIM *604539), cardiac valvular (COL1A2, MIM *120160), kyphoscoliotic (PLOD, MIM *153454; FKBP14, MIM *614505), and arthrochalasia (COL1A1, MIM *120150; COL1A2) EDS subtypes, also sharing with cEDS several cutaneous and articular issues, are generally distinguishable for the presence of specific hallmarks (Brady et al., 2017; Malfait et al., 2017). This evidence concerns the gene COL1A2 and Ehlers-Danlos syndrome.