A combination of exome-wide and genome-wide association studies (GWAS) have led to the identification of five loci (rs738409 in PNPLA3 (4), rs58542926 near TM6SF2 (5), rs72613567 in HSD17B13 (6), rs641738 near TMC4-MBOAT7 (7–9) and rs2642438 in MTARC1 (10)) linked to NASH (11), fibrosis (12) and hepatocellular carcinoma (HCC) (13) in patients with NAFLD. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatohepatitis.