Inhibits copper containing enzymes tyrosinase and dopamine β-hydroxylase (Hashiguch and Takahashi, 1976), shown to re-activate hypoxia-inducible factor 1α (HIF-1α) and reduce renal fibrosis in a rat model of renal ablation (Yu et al., 2012), blocks proliferation in prostate carcinoma cells (Chung et al., 2012) and breast cancer cells (Kulp and Vulliet, 1996). The gene discussed is HIF1A; the disease is breast cancer.