Although there was no overall effect of gonadectomy, we observed a strong interaction between the effect of Rictor loss and ovariectomy (p=0.014), and the survival curves of L-RKO OVX mice overlap the survival curves of WT Sham and WT OVX, leading us to interpret this interaction as demonstrating a strong protective effect of ovariectomy against a non-cancer related cause of death in mice lacking hepatic Rictor. Here, RICTOR is linked to cancer.