Medulloblastoma cases with elevated REST expression are often associated with a more dismal prognosis, frequent occurrence of metastasis, and poor overall survival compared to ‘REST‐low’ and ‘REST‐negative’ tumors (Su, Kameoka, Lentz, & Majumder, 2004; Taylor et al., 2012; Wu et al., 2012). This evidence concerns the gene REST and medulloblastoma.