REST and neoplasm: Both in vivo and in vitro studies demonstrated that treatment with HDACi reduces tumor cell growth; however, it remains unclear whether the high REST expression contributes to the sensitivity of tumor cells due to the domination of HDACs in its repression complexes (Häcker et al., 2011; Ma et al., 2009; Nesterenko, Wanningen, Bagci‐Onder, Anderegg, & Shah, 2012).