In several studies, upregulated REST expression in medulloblastomas has been suggested to maintain the self‐renewal potential of tumor cells by repressing the expression of neuronal differentiation genes (Conti et al., 2012; Fuller et al., 2005; Gao et al., 2011; Gonçalves da Silva et al., 2017; Taylor et al., 2012). This evidence concerns the gene REST and neoplasm.