AKR1A1 and Coma: The effect of alcohol varies from person to person depending on metabolism, such as alcohol dehydrogenase activity, but a common guideline for the effect of alcohol is as follows: very low BACs (<100 mg/L) produce zero or undetectable effects; BAC of 300 mg/L produces impairment of motor skills; BAC of 1.5 g/L produces gross motor impairment; and BAC of 2 g/L produces amnesia and coma (Harrison et al., 2017; Jamebozorgi et al., 2013).