Consistent with the important role of ISGs in the effect of FGF7, MxA (human myxovirus resistance protein) and OAS1 (2′‐5′‐oligoadenylate synthase 1), two ISGs that are highly expressed during infection by viruses of the Flaviviridae family (Zhu et al, 2014), were upregulated during ZIKV infection, and FGF7 antagonized this effect (Fig 6I and J). This evidence concerns the gene OAS1 and Zika virus infectious disease.