AIRE and neuropathy: They have also been associated with neuropathies including SFN.61 Indirect genetic risks have been identified as well; for instance, MYD88 L265P is a common risk for Waldenström’s macroglobulinemia,62 which conveys risk for neuropathy, presumably from clonal autoantibodies targeting nerve epitopes.63,64 Mice deficient in the autoimmune regulator (AIRE) gene develop symtoms of Sjögren’s syndrome plus SFN detectable in the cornea and lachrymal glands.65 Given the strong risk that Sjögren’s poses for developing SFN,21AIRE variants may prove to be human risk factors for SFN.