Crosstalk between the tumor ECM and growth factor receptors (like EGFR) has been further shown to play an important functional role in mediating tumor progression and metastasis (Wu et al., 2004; Reticker-Flynn et al., 2012; Du et al., 2013; Kim et al., 2014; Stevens et al., 2017). This evidence concerns the gene EGFR and neoplasm.