ECM molecules like Fibulin-3, Tenascin-C and Emilin-2 have been known to associate with growth factor receptors like EGFR to regulate its activation and function during cancer progression (Iyer et al., 2008; Grahovac and Wells, 2014; Kim et al., 2014; Paulitti et al., 2018). This evidence concerns the gene EFEMP1 and cancer.