For example, our data, and the FANTOM5 data, reveal that the transcript encoding the key regulator CDC25B, which is essential for G2/M cell cycle progression in AML (Didier et al., 2008) is expressed in THP-1 cells but is primarily driven by a cluster of three promoters that are internal to the annotated TSS in RefSeqs NM_001287516, NM_001287517, and NM_001287518. The gene discussed is CDC25B; the disease is acute myeloid leukemia.