Note that by contrast to earlier studies (Nguyen et al., 2011; Garrison et al., 2017; Germano et al., 2017; Prange et al., 2017) (see section “Introduction”) the set of down-regulated transcripts did not include KMT2A (MLL), DOT1L, RUNX1 or ZNF521, implicated in primary leukemogenic transformation in AML. This evidence concerns the gene ZNF521 and acute myeloid leukemia.