BACE1 and Alzheimer disease: Bisecting GlcNAc modifications have shown the capacity to stabilize BACE1 protein under conditions of oxidative stress (Kizuka et al., 2016a), and the increased contents of bisecting GlcNAc in AD brains might function as an adaptive response, which protects the brains from the damage caused by additional beta-amyloid yields (Akasaka-Manya et al., 2010).