Akasaka-Manya et al. discovered that the mRNA levels of mgat3 were elevated in the temporal cortex of the brain in patients with Alzheimer's disease (AD) (Akasaka-Manya et al., 2010), which accelerated studies on the tissue distribution of GlcNAc-T III expression, with the conclusion that it was most highly expressed in the nervous system (Shimizu et al., 1993; Kizuka et al., 2016b; Kizuka and Taniguchi, 2018). Here, MGAT3 is linked to early-onset autosomal dominant Alzheimer disease.