CNS-involvement in systemic inflammatory/rheumatic diseases
For example, Takayasu arteritis, polyarteritis nodosa, Kawasaki disease, Henoch-Schönlein purpura, Behçet disease, granulomatosis with polyangiitis, microscopic polyangiitis, systemic lupus erythematosus, juvenile dermatomyositis, inflammatory bowel disease, hemophagocytic lymphohistiocytosis, ADA 2-deficiency, TREX1-associated diseases (e.g., Aicardi-Goutieres syndrome). The gene discussed is TREX1; the disease is granulomatosis with polyangiitis.