In the present study, we found that brachyury plays a role of promoting cell proliferation in lung H460 cells, which is consistent with our previous study of brachyury on breast cancer cells (9) and other reports on chordoma (3, 6, 19, 20), prostate cancer (21), colorectal cancer (22),adenoid cystic carcinoma (13), among others (20, 21). The gene discussed is TBX1; the disease is chordoma.