Because CXCR4 is induced in EWS cells exposed to hypoxia (13), a common condition of human tumor microenvironment (40), we investigated the contribution of the IGF2BP3/CD164/CXCR4 axis on CXCL12-evoked biological responses of EWS cells under normoxic (21% O2) or hypoxic conditions (1% O2). Here, CXCL12 is linked to neoplasm.