Moreover, the expression of METTL3 was also significantly correlated to expression of all other differentially expressed m6A RNA methylation regulators in endometrium of cases versus controls, including YTHDC1, FTO, and ZC3H13 (Figure 1D, Spearman R) without any change in the expression of WATP. Therefore, METTL3 is a prime candidate as the “hub” gene of m6A RNA methylation regulators involved in endometrial dysfunction in the setting of adenomyosis. The gene discussed is ZC3H13; the disease is adenomyosis.