Decreased METTL3 and total m6A levels in endometrium of adenomyosis patients may contribute to cell proliferation and invasion through IGF1 and DDT. The RNA methylation levels of specific and target genes such as IGF1, DDT, PLAC8, and SCN4B remain to be investigated using methods such as methylated RNA immunoprecipitation sequencing (MeRIP-seq) and MeRIP-qPCR. This evidence concerns the gene IGF1 and adenomyosis.