PLAC8 and adenomyosis: Additionally, PLAC8, a multi-faceted protein involved in various cellular physical processes (such as the regulation of immunity, cell differentiation and apoptosis) (Li et al., 2014), was also increased in the myometrium in adenomyosis patients and was closely related to m6A RNA methylation regulator “cluster.” Thus, the myometrium has processes in place for immune cell response in the setting of adenomyosis, associated with m6A RNA methylation regulators.