The expression difference of every individual gene presented the same tendency between two GEO data sets in MS, and CAMK2G was also upregulated in IS GEO data sets, whereas three of five genes (CLEC2D, LBH, and SLC2A4RG) had opposite alterations in GSE16561 and GSE58294, which might be due to the heterogeneity of IS and its subtypes. This evidence concerns the gene CLEC2D and myeloid sarcoma.