TNFRSF1A and cancer: The TNFRSF10A missense variations might therefore modify CS response by keeping a fine balance between degeneration and regeneration, as reported by Fisher et al. in mdx mice (Fisher et al., 2005), thus reducing necrosis, as reported in cancer, by decreasing expression of death receptors (including TNFR), and eventually reducing apoptosis (Runnebaum and Brüning, 2005).