IRF3 and systemic lupus erythematosus: A previous study suggested that rs2304206 in IRF3 (which has intermediate LD with rs7251: R2 = 0.68 in Europeans, R2 = 0.43 in East Asians between the two SNPs) could be associated with SLE, based on a cohort of Mexican Mestizo descent with 156 SLE patients and 272 controls (Santana-de Anda et al., 2014).