Using several animal models of colon cancer, such as azoxymethane (AOM)-dextran sodium sulfate, IL-10 knock-out, and 1,2-dimethylhydrazine-induced colon cancer in mice and rats, studies have suggested that probiotics may inhibit cancer development and progression by inactivating mutagens or carcinogens, modulating intestinal microflora and their metabolism, inducing apoptosis, and inhibiting tumor cell differentiation by suppressing tumor-promoting signaling pathways and immunomodulation [reviewed in (83, 84)]. This evidence concerns the gene IL10 and neoplasm.