Whilst the role of GluN1 autoantibodies in disease pathogenesis has been the key focus, more recently a mouse model of NMDAR encephalitis involving active immunization with intact native-like NMDAR GluN1/GluN2B tetramers embedded in a liposome scaffold has been described that recapitulates a broader range of features reminiscent of that found in the human disease (29). Here, GRIN1 is linked to encephalitis.