Serum GluN1 autoantibodies are found in healthy older adults and there is increased seroprevalence (>20%) in individuals affected by a wide-range of diseases including stroke, neuropsychiatric illnesses, and dementia (41–45), with a recent study suggesting GluN1 autoantibodies may be part of the normal autoimmune repertoire (46). The gene discussed is GRIN1; the disease is Stroke.