A dichotomy between the role of ACE2 expression in young (who are expected to have higher levels of the enzyme) or older adults (with age-dependent lower ACE2 levels and exacerbation of the angiotensin II pro-inflammatory arm) in COVID-19 outcomes is beginning to take shape (AlGhatrif et al., 2020; Bavishi et al., 2020). The gene discussed is ACE2; the disease is COVID-19.