The first reports that associate LMNA mutations to cardiac diseases date back to 1999 (Bonne et al., 1999; Fatkin et al., 1999): these reports represented a revolution in the field, identifying for the first time LMNA mutations as responsible for dilated cardiomyopathy (DCM) associated with conduction system disease. The gene discussed is LMNA; the disease is familial dilated cardiomyopathy.