More recently, similarly to what reported in other cellular models of laminopathy, the pathogenesis of the LMNA-CMP has been linked to the “gene expression/chromatin organization hypothesis,” showing a causal association between LMNA mutations, transcription and specific cell phenotypes (Bertero et al., 2019; Lee et al., 2019; Salvarani et al., 2019). The gene discussed is LMNA; the disease is laminopathy.