However, because of their efficacy in inducing deeper molecular remission, an essential criterion for treatment cessation (i.e., BCR-ABL1 transcript below 0.01% for at least 2 years), they have been approved for the treatment of chronic-phase CML in first line (Brummendorf et al., 2015; Cortes et al., 2016; Hochhaus et al., 2016; National Comprehensive Cancer Network, 2019). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.