IGF1R and Alzheimer disease: Consistent with these findings, a body of studies have demonstrated that genetically ablating IGF-1R signaling improves neuroprotection and protects against AD progression by alleviating AD hallmarks including Aβ deposition, neuroinflammation, neuronal and synaptic loss, and behavioral dysfunction in AD mouse models (Cohen et al., 2009; Freude et al., 2009; Gontier et al., 2015; George et al., 2017).