Possibly the drug treatment-dependent effects on acute IGF-1R-related signaling responses are transiently detectable as prior work has shown that rapamycin treatment did not change the levels of total or phosphorylated mTOR although it did decrease levels of Aβ42 and deposition, tau pathology, and early learning and memory impairments in 3xTg AD mice (Caccamo et al., 2010). This evidence concerns the gene MAPT and Alzheimer disease.