APP and Alzheimer disease: In this study, we quantified the retinal expression of Aβ by comparing in vivo curcumin fluorescence obtained from fluorescence scanning laser ophthalmoscopy (fSLO) with retinal and brain immunohistological labeling of Aβ in the APP/PS1 mouse model of AD in order to compare the brain and eye deposition of Aβ in young and old APP/PS1 transgenic (Tg) and wild-type (WT) mice and investigate the potential of in vivo retinal imaging with curcumin labeling as a surrogate method for quantifying Aβ load in the brain.