The lack of G6PD reduces the generation of nicotinamide adenine dinucleotide phosphate (NADPH), thus causing reactive oxygen species (ROS) accumulation.6,7 Studies have demonstrated that the ROS-mediated activation of the c-Jun N-terminal kinase (JNK) pathway impedes tumour progression by inducing cell apoptosis.8,9. This evidence concerns the gene G6PD and neoplasm.