Epithelial-mesenchymal transition (EMT), the initial step in cancer metastasis, is a process by which epithelial cells lose cell polarity and intercellular connections and gain enhanced cell migration and invasion capacities.10,11 E-Cadherin, an EMT regulatory molecule, plays an inhibitory role in cancer metastasis by blocking cell migration or invasion.12–14 Moreover, post-translational modification of E-Cadherin, especially bisecting and β1,6-GlcNAc-branched N-glycosylation, plays crucial role in metastasis regulation.15,16. This evidence concerns the gene CDH1 and cancer.