DPAGT1, encoding the enzyme catalysed the initial step of N-glycan biosynthesis,42 has been reported to be a target of β-catenin.43 Its overexpression in oral cancer has been associated with aberrant N-glycosylation and enhanced cell migration.44,45 This indicated that E-Cadherin-β-catenin-DPAGT1 cycle could engage in the crosstalk between the expression and N-glycosylation of E-Cadherin. The gene discussed is CDH1; the disease is lip and oral cavity carcinoma.