High-grade AEs, including hypertension (n = 5, 22%), proteinuria (n = 4, 17%), hand-foot syndrome (HFS) (n = 4, 17%), leukopenia (n = 2, 9%), and elevated ALT (n = 2, 9%) were reported in at least two patients of arm E (Table 2). The gene discussed is GPT; the disease is hypertensive disorder.