The most common treatment-related AEs of any grade were anemia (n = 46, 67%), leukopenia (n = 41, 59%), neutropenia (n = 30, 43%), thrombocytopenia (n = 28, 41%), fatigue (n = 26, 38%), hypertension (n = 18, 26%), proteinuria (n = 18, 26%), and elevated alanine aminotransferase (ALT) (n = 17, 25%) (Supplementary information, Table S3). This evidence concerns the gene GPT and anemia.