CD4 and Autoimmunity: A host-protective role of TRM cells has also been evidenced in the context of chronic infections with pathogenic viruses, such as HSV and CMV.71 In human tissues, CD4+ or CD8+ TRM cells have been identified, including those specific to CMV, RSV, Epstein-Barr virus, HSV, HBV, HIV, and IAV54 and correlations have been made between increased populations of virus-specific TRM cells and enhanced viral control.72–75 Moreover, growing evidence points toward a role for TRM cells in inflammatory disorders and autoimmunity, both in humans and mice.69