In NPM1-mutated AML, HOXB-AS3, a lncRNA embedded in the HOXB locus, binds to p48 EBP1 and guides it to rDNA, where it augments the interaction of EBP1 with NPM in the nucleolus, ultimately contributing to efficient protein translation54. This evidence concerns the gene PA2G4 and acute myeloid leukemia.