FBXW7 and neoplasm: In contrast, a tumor suppressor function of FBXW7 was accelerated by p42 EBP1, enhancing the association of FBXW7 and its oncogenic targets, including c-Myc, Aurora-A, and cyclin E. At the same time, p48 EBP1 contributes to the relocalization of FBXW7 from the nucleus to the cytoplasm, where it is not able to bind to its oncogenic nuclear targets36.