CRLF3 and neoplasm: In contrast to the tumor-suppressive activity of p42 EBP1, reflecting the anti-apoptotic and growth-promoting activities of p482,38, p48 EBP1 is expressed at high levels in cancer cells25, including GBM6, anaplastic large cell lymphoma39, colorectal cancer40 and acute myeloid leukemia (AML)41.