Moreover, we observed that CPX treatment resulted in PARP and caspase-3 cleavage as well as promoting CHOP expression in a dose-dependent manner (Fig. 7e), but pretreatment of with ROS scavenger NAC rescued CRC cells from this CPX-induced apoptosis and reversed the upregulation of CHOP (Fig. 7f). This evidence concerns the gene DDIT3 and colorectal carcinoma.