MMP9 and colorectal carcinoma: Immunoblotting analysis showed that the protein expression of epithelial marker E-cadherin was increased, while the expression of mesenchymal markers N-cadherin and Snail were markedly reduced in CPX-treated CRC cells (Fig. 3e, f) and MMP-2 and MMP-9 expression levels were also decreased in a dose-dependent manner (Fig. 3e, f).