To assess the independent prognostic value after adjuvant chemotherapy of BRCA1 hypermethylation alone or in combination with BRCA1-null status, we performed multivariable Cox regression analysis adjusting for tumor size (≤20 mm, >20 mm), patient age (<40, 40–59, and ≥60 years), tumor grade (2, 3), and lymph node status (N0, N+) using IDFS as the clinical endpoint. The gene discussed is BRCA1; the disease is neoplasm.