To test the hypothesis that BRCA1 hypermethylation confers a similar genetic and genomic tumor phenotype as BRCA1-null tumors we compared an array of readouts from WGS between the two groups using the combined SCAN-B and Nik-Zainal et al.24 cohorts (n = 57 hypermethylated and n = 52 BRCA1-null cases in total, Fig. 1). The gene discussed is BRCA1; the disease is neoplasm.