Furthermore, SIRT7-silenced endothelial cultures produced higher levels of TGFβ1, a potent anti-inflammatory cytokine that is released during the fibroproliferative stage of ALI and may contribute both to EndoMT49,50 and blunted inflammatory responses to LPS in the lung endothelium. The gene discussed is TGFB1; the disease is acute respiratory distress syndrome.