Although the highest levels of Naa10p were found in AR-containing PCa cell lines, levels of Naa10p in AR-null cell lines were also relatively higher than those in normal prostatic epithelial cell lines18, suggesting other sets of genes in androgen-AR axis-independent PCa cells are regulated by Naa10p through a non-AR-dependent signaling pathway. The gene discussed is AR; the disease is posterior cortical atrophy.