INS and Hypoglycemia: In addition to the advantages that this type of distribution would have to minimize the risk of hypoglycaemia due to variations in oral absorption (see section below on hypoglycaemia assessment), it could be speculated that an insulin analogue with strong albumin binding having a rapid, peaked central (blood compartment) PK profile would mimic the pattern of insulin secreted from the pancreas directly into the portal circulation where the liver is highly exposed.