As SM induce the rapid degradation of BIRC2 and XIAP in cancer cells and HIV-TCM19,24,25,29–31, we evaluated the ability of the SM LCL-161, AT-406, and birinapant to induce BIRC2 and XIAP degradation in uninfected macrophages and HIV-Mφ. This evidence concerns the gene BIRC2 and cancer.