In a logistic regression model adjusted for baseline submicroscopic and microscopic parasitemia, age groups, blood hemoglobin, bed net use, sex and community of residence, there was a significant association between baseline anti-schizont IgG (OR = 0.44, 95% CI = 0.20 to 0.99; P = 0.046) and protection against febrile malaria but not for IgM (P = 0.36) (Table 4). This evidence concerns the gene CD40LG and parasitic infectious disease.