The two DMD zebrafish lines, sapje and sapje-like, harbor mutations in the dystrophin gene that both result in absence of the dystrophin muscle protein causing extensive muscle degeneration, inflammation, and fibrosis similar to the pathogenesis of human DMD (Bassett and Currie, 2004; Guyon et al., 2009). This evidence concerns the gene DMD and Duchenne muscular dystrophy.