Under the dominant model, subjects with the EPAS1-rs6756667 GA/AA genotype were less likely to suffer from AMS-related GI symptoms (OR = 0.53; 95% CI 0.32–0.89; P = 0.013), and the result was marginally significant after FDR correction (Q = 0.052). This evidence concerns the gene EPAS1 and ablepharon macrostomia syndrome.