Ultimately, 4 SNPs (EGLN1-rs2153364, EPAS1-rs6756667, VEGFA-rs3025039 and PPARA-rs7292407) were found to be associated with the risk of developing AMS, even after adjusted by age, BMI and smoking status, as well as the results after FDR correction. Here, EGLN1 is linked to ablepharon macrostomia syndrome.