EPAS1 and ablepharon macrostomia syndrome: Ultimately, 4 SNPs (EGLN1-rs2153364, EPAS1-rs6756667, VEGFA-rs3025039 and PPARA-rs7292407) were found to be associated with the risk of developing AMS, even after adjusted by age, BMI and smoking status, as well as the results after FDR correction.